Technology

LENTISOMA

Episomal non-integrative Lentiviral vector that provides the lasting, stable and consistent expression of the transgene in dividing and non-dividing cells without modifying the cell genome through integration

LENTISOMA

Episomal non-integrative Lentiviral vector that provides the lasting, stable and consistent expression of the transgene in dividing and non-dividing cells without modifying the cell genome through integration.

Lentisoma

Innovation

  • Lentisoma technology is a new generation of non-integrative lentiviral vectors.
  • Lentisoma is designed for stable gene transfer in cells and tissues, regardless the division rate without integration.
  • Patented technology (USA, Europa, Japan etc…)

OUSTANDING FEATURES

  • Lentisoma provides in a simple and effective way, the lasting, stable and consistent expression of the transgene in dividing and non-dividing cells without modifying the cell genome through integration.
  • Lentisoma vector incorporates specific eukaryotic sequences, which direct both the binding of the viral genome with the nuclear matrix (S/MAR sequences) and its duplication through the replication of cell DNA (ori sequence). Lentisoma is generated with a class I mutation in the viral integrase, so the intranuclear viral genome forms are circular episomes.
  • These facts allow to extend lentiviral vectors clinical use, widening their application to indications in which the modification of tissues or cells with high division rates is required.

Contact with us

Mikeletegi Pasealekua 81, San Sebastián 20009, Gipuzkoa (SPAIN)

  • dummy+34 943 308 568

  • dummy info@vivebiotech.com

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