Optimization

VIVEbiotech has process optimization departments for both Upstream (USP) production and Downstream (DSP) purification, with the final objective of obtaining an efficient, scalable and regulatory-compliant production process to provide our clients with functional and cost-effective vectors manufactured in reactors.

Importantly, VIVEbiotech´s manufacturing platform is the same for Developmental Engineering and GMP batches.

 

The Upstream Development Department is in charge of:

  • Adjusting the initial seed-train expansion process.
  • Defining optimal seeding conditions for bioreactors.
  • Selecting the best conditions for transfection.
  • Defining the optimal conditions for harvesting.
  • Determining in-process controls (IPCs).
  • Testing new technologies with the constant objective of enhancing productivity during USP.

The Downstream Development Department is in charge of:

  • Optimizing chromatographic process performance.
  • Adjusting tangential flow filtration (TFF).
  • Developing the best approach to Fill & Finish (F&F) operations.
  • Determining in-process controls (IPCs).
  • Testing new technologies with the constant objective of enhancing productivity during DSP.

Once our development and optimization strategy has been completed, our ultimate goal is to transfer these improvements to benefit the services provided to our customers.